Look at the labels on all your medicines to see when they have acetaminophen, and request your pharmacist When you are Uncertain.
The concomitant usage of OXYCONTIN and CYP3A4 inducers can lessen the plasma focus of oxycodone [see CLINICAL PHARMACOLOGY], resulting in lowered efficacy or onset of the withdrawal syndrome in people who've formulated Actual physical dependence to oxycodone [see WARNINGS AND PRECAUTIONS].
Based on facts obtainable over the metabolism and excretion of oxycodone, dose initiation in individuals with renal impairment should really stick to a conservative solution. Dosages needs to be modified in accordance with the clinical predicament.
Oxycodone hydrochloride tablets are meant for oral use only. Abuse of oxycodone hydrochloride tablets poses a possibility of overdose and Dying. The chance is increased with concurrent abuse of alcohol and also other substances.
Selection of sufferers for cure with oxycodone hydrochloride tablets ought to be governed by precisely the same concepts that utilize to the use of other potent opioid analgesics. Opioid analgesics provided on a set-dosage plan Use a slender therapeutic index in certain affected person populations, particularly when blended with other drugs, and will be reserved for scenarios where by the key benefits of opioid analgesia outweigh the regarded challenges of respiratory despair, altered psychological condition, and postural hypotension.
Due to the pitfalls linked with accidental ingestion, misuse, and abuse, suggest clients to retail outlet OXYCONTIN securely, away from sight and access of kids, As well as in a site not accessible by Other individuals, which include site visitors to the house.
Extended-expression experiments haven't been executed in animals To guage the carcinogenic opportunity of oxycodone hydrochloride tablets or oxycodone. The attainable effects on male or feminine fertility haven't been examined in animals.
The dosage relies read more on your health care condition and response to procedure. Usually do not boost your dose, take the medication far more normally, or get it for an extended time than prescribed. Properly cease the medication when so directed.
Do not use with every other drug containing acetaminophen without inquiring your doctor or pharmacist initial. click here Acetaminophen is in many nonprescription and prescription medications (such as pain/fever drugs or cough-and-chilly products and solutions).
Examine patients for signs of click here diminished diuresis and/or results on blood pressure level and enhance the dosage of the diuretic as necessary.
Shut observation and Recurrent titration are warranted right until pain management is secure on The website brand new opioid. Observe people for signals and symptoms of opioid withdrawal and for indications of oversedation/toxicity after changing clients to OXYCONTIN.
Immediately after stopping a CYP3A4 inducer, as the effects with the inducer decline, the oxycodone plasma focus will enhance [see CLINICAL PHARMACOLOGY], which could raise or extend both the therapeutic outcomes and adverse reactions and may induce critical respiratory depression.
Advise individuals that OXYCONTIN may perhaps impair the chance to conduct possibly dangerous activities including driving a car or truck or operating weighty equipment. Recommend clients to not accomplish this sort of jobs until they know how they're going to respond to the medication [see WARNINGS AND PRECAUTIONS].
If the choice is built to prescribe a benzodiazepine or other CNS depressant concomitantly with an opioid analgesic, prescribe the lowest successful dosages and least durations of check here concomitant use. In patients presently obtaining an opioid analgesic, prescribe a lessen Original dose of your benzodiazepine or other CNS depressant than indicated from the absence of the opioid, and titrate based on clinical response.